INTRANET

Clément Mettling

Research Scientist

I have acquired a background in molecular biology by working on various topics including neurodegenerative diseases and AIDS. My current project in the human evolutionary biology team focuses on adaptation to risk. We have recently shown a genetic selection of the dopamine receptor DRD4 in a volcanic area. We would like to confirm this result in other volcanoes, and conduct a genomic study to characterize other loci involved in risk taking.

 

39 documents

  • Yea-Lih Lin, C. Mettling, P. Portales, B. Reant, V. Robert-Hebmann, et al.. The efficiency of R5 HIV-1 infection is determined by CD4 T-cell surface CCR5 density through Galphai-protein signalling. AIDS. Official journal of the international AIDS Society, 2006, 20, pp.1369-1377. ⟨10.1097/01.aids.0000233570.51899.e2⟩. ⟨hal-00082331⟩
  • Jf Guichou, J. Viaud, C. Mettling, G. Subra, Yea-Lih Lin, et al.. Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.. Journal of Medicinal Chemistry, 2006, 49 (3), pp.900-910. ⟨10.1021/jm050716a⟩. ⟨hal-00113407⟩
  • E. Bachrach, H. Dreja, Y. L. Lin, C. Mettling, V. Pinet, et al.. Effects of virion surface gp120 density on infection by HIV-1 and viral production by infected cells. Virology, 2005, 332 (1), pp.418--29. ⟨10.1016/j.virol.2004.11.031⟩. ⟨hal-02262222⟩
  • Carole Crozet, Yea-Lih Lin, Clément Mettling, Chantal Mourton-Gilles, Pierre Corbeau, et al.. Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations.. Journal of Cell Science, 2004, 117 (Pt 23), pp.5591-7. ⟨10.1242/jcs.01484⟩. ⟨inserm-00143203⟩
  • A Giangrande, C Mettling, M Martin, C Ruiz, G Richards. Drosophila Sgs3 TATA: effects of point mutations on expression in vivo and protein binding in vitro with staged nuclear extracts.. EMBO Journal, 1989, 8 (11), pp.3459-66. ⟨hal-03478183⟩
  • Marianne Martin, Clément Mettling, Angela Giangrande, Claude Ruiz, Geoff Richards. Regulatory elements and interactions in theDrosophila 68C glue gene cluster. Developmental Genetics, 1989, 10 (3), pp.189-197. ⟨10.1002/dvg.1020100308⟩. ⟨hal-03478180⟩
  • Clément Mettling, Angela Giangrande, Geoff Richards. The use of oligonucleotide probes in studies of insect gene activity in development. Journal of Insect Physiology, 1988, 34 (7), pp.679-684. ⟨10.1016/0022-1910(88)90077-7⟩. ⟨hal-03478161⟩
  • A Giangrande, C Mettling, G Richards. Sps-3 transcript levels are determined by multiple remote sequence elements.. EMBO Journal, 1987, 6 (10), pp.3079-84. ⟨hal-03475626⟩
  • Clément Mettling, Angela Giangrande, Geoff Richards. The Drosophila sgs3 gene: an in-vivo test of intron function. Journal of Molecular Biology, 1987, 196 (1), pp.223-226. ⟨10.1016/0022-2836(87)90523-7⟩. ⟨hal-03475625⟩

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Clément Mettling

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