INTRANET

Clément Mettling

Research Scientist

I have acquired a background in molecular biology by working on various topics including neurodegenerative diseases and AIDS. My current project in the human evolutionary biology team focuses on adaptation to risk. We have recently shown a genetic selection of the dopamine receptor DRD4 in a volcanic area. We would like to confirm this result in other volcanoes, and conduct a genomic study to characterize other loci involved in risk taking.

 

39 documents

  • Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel A. Sanz, Anna Biernacka, et al.. Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites. Nature Communications, 2020, 11 (1), pp.3940. ⟨10.1038/s41467-020-17858-2⟩. ⟨hal-02931000⟩
  • F. Coquel, M. Silva, H. Técher, K. Zadorozhny, S. Sharma, et al.. SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron. Comptes Rendus. Biologies, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩. ⟨hal-03078628⟩
  • F. Coquel, M. Silva, H. Técher, K. Zadorozhny, S. Sharma, et al.. SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron. Comptes Rendus. Biologies, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩. ⟨hal-03083188⟩
  • Christophe Chopard, Phuoc Bao Viet Tong, Petra Toth, Malvina Schatz, Hocine Yezid, et al.. Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nature Communications, 2018, 9 (1), pp.2251. ⟨10.1038/s41467-018-04674-y⟩. ⟨hal-02146273⟩
  • Charline Duquenne, Sandrine Gimenez, Adeline Guigues, Benjamin Viala, Caroline Boulouis, et al.. Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling. AIDS. Official journal of the international AIDS Society, 2017, 31 (18), pp.2443 - 2454. ⟨10.1097/QAD.0000000000001649⟩. ⟨hal-01635726⟩
  • Charlotte Faurie, Clement Mettling, Mohamed Ali Bchir, Danang Hadmoko, Carine Heitz, et al.. Evidence of genotypic adaptation to the exposure to volcanic risk at the dopamine receptor DRD4 locus. Scientific Reports, 2016, 6 (37745), 7 p. ⟨10.1038/srep37745⟩. ⟨hal-02062364⟩
  • Yw Wu, C Mettling, Sr Wu, Cy Yu, Gc Perng, et al.. Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Scientific Reports, 2016, 6, pp.32243. ⟨10.1038/srep32243⟩. ⟨hal-01377127⟩
  • Solène Debaisieux, Simon Lachambre, Antoine Gross, Clément Mettling, Sébastien Besteiro, et al.. HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup. Nature Communications, 2015, 6 (1), pp.6211. ⟨10.1038/ncomms7211⟩. ⟨hal-02146268⟩
  • C Duquenne, C Psomas, S Gimenez, A Guigues, Mj Carles, et al.. The Two Human CXCR4 Isoforms Display Different HIV Receptor Activities: Consequences for the Emergence of X4 Strains. Journal of Immunology, 2014, 193 (8), pp.4188-4194. ⟨10.4049/jimmunol.1303298⟩. ⟨hal-01074809⟩
  • Ming-Yi Shen, Yan-Jun Liu, Ming-Jaw Don, Hsien-Yueh Liu, Zeng-Weng Chen, et al.. Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica. PLoS ONE, 2011, 6 (11), pp.e27480. ⟨10.1371/journal.pone.0027480⟩. ⟨hal-00645719⟩

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Clément Mettling

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