Clément Mettling
Research Scientist
I have acquired a background in molecular biology by working on various topics including neurodegenerative diseases and AIDS. My current project in the human evolutionary biology team focuses on adaptation to risk. We have recently shown a genetic selection of the dopamine receptor DRD4 in a volcanic area. We would like to confirm this result in other volcanoes, and conduct a genomic study to characterize other loci involved in risk taking.
11 documents
- Malvina Schatz, Laetitia Marty, Camille Ounadjela, Phuoc Bao Viet Tong, Ilaria Cardace, et al.. A Tripartite Complex HIV-1 Tat-Cyclophilin A-Capsid Protein Enables Tat Encapsidation That Is Required for HIV-1 Infectivity. Journal of Virology, 2023, 97 (4), ⟨10.1128/jvi.00278-23⟩. ⟨hal-04106774⟩
- Gwen-Jirō Clochard, Aby Mbengue, Clément Mettling, Birane Diouf, Charlotte Faurie, et al.. The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen. Scientific Reports, 2023, 13 (1), pp.622. ⟨10.1038/s41598-022-27002-3⟩. ⟨hal-03954770⟩
- Lucy Kundura, Sandrine Gimenez, Renaud Cezar, Sonia André, Mehwish Younas, et al.. Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19. Journal of Allergy and Clinical Immunology, 2022, 150 (3), pp.594-603.e2. ⟨10.1016/j.jaci.2022.06.020⟩. ⟨hal-03837641⟩
- Vo-Minh-Hoang Bui, Clément Mettling, Jonathan Jou, H Sunny Sun. Genomic amplification of chromosome 20q13.33 is the early biomarker for the development of sporadic colorectal carcinoma. BMC Medical Genomics, 2020, 13, ⟨10.1186/s12920-020-00776-z⟩. ⟨hal-03078496⟩
- Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel A. Sanz, Anna Biernacka, et al.. Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-17858-2⟩. ⟨hal-02931000⟩
- F. Coquel, M. Silva, H. Técher, K. Zadorozhny, S. Sharma, et al.. SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron. Comptes Rendus Biologies, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩. ⟨hal-03078628⟩
- Christophe Chopard, Phuoc Bao Viet Tong, Petra Toth, Malvina Schatz, Hocine Yezid, et al.. Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells. Nature Communications, 2018, 9 (1), pp.2251. ⟨10.1038/s41467-018-04674-y⟩. ⟨hal-02146273⟩
- Flavie Coquel, Maria-Joao Silva, Hervé Techer, Karina Zadorozhny, Sushma Sharma, et al.. SAMHD1 acts at stalled replication forks to prevent interferon induction. Nature, 2018, 557 (7703), pp.57 - 61. ⟨10.1038/s41586-018-0050-1⟩. ⟨hal-01791237⟩
- Charline Duquenne, Sandrine Gimenez, Adeline Guigues, Benjamin Viala, Caroline Boulouis, et al.. Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling. AIDS. Official journal of the international AIDS Society, 2017, 31 (18), pp.2443 - 2454. ⟨10.1097/QAD.0000000000001649⟩. ⟨hal-01635726⟩
- Charlotte Faurie, Clement Mettling, Mohamed Ali Bchir, Danang Hadmoko, Carine Heitz, et al.. Evidence of genotypic adaptation to the exposure to volcanic risk at the dopamine receptor DRD4 locus. Scientific Reports, 2016, 6 (37745), 7 p. ⟨10.1038/srep37745⟩. ⟨hal-02062364⟩
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