INTRANET

Clément Mettling

Chargé de Recherche

J'ai acquis une formation en biologie moléculaire en travaillant sur différentes thématiques dont les maladies neuro-dégénératives et le SIDA. Mon projet actuel au sein de l'équipe de biologie évolutive humain porte sur l'adaptation au risque. Nous avons récemment montré une sélection génétique du récepteur à la dopamine DRD4 dans une zone volcanique. Nous aimerions confirmer ce résultat sur d'autres volcans, et mener une étude génomique afin de caractériser d'autres loci intervenant dans la prise de risque.

 

39 documents

  • I. de Vidi, G. Boursier, N. Delouche, P. Portales, E. Cadars, et al.. Strategy for anti-aquaporin-4 auto-antibody identification and quantification using a new cell-based assay. Clinical Immunology, 2011, 138 (3), pp.239-246. ⟨10.1016/j.clim.2010.11.012⟩. ⟨hal-00575112⟩
  • Fabienne Rayne, Solène Debaisieux, Hocine Yezid, Yea-Lih Lin, Clément Mettling, et al.. Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells. EMBO Journal, 2010, 29 (8), pp.1348-1362. ⟨10.1038/emboj.2010.32⟩. ⟨hal-02147182⟩
  • Yea-Lih Lin, C. Mettling, P. Portales, Roman Rouzier, J. Clot, et al.. The chemokine CCL5 regulates the in vivo cel surface of its receptor, CCR5. AIDS. Official journal of the international AIDS Society, 2008, 22 (3), pp.430-432. ⟨10.1097/QAD.0b013e3282f46a6f⟩. ⟨hal-00206135⟩
  • C. Mettling, C. Desmetz, Al Fiser, B. Reant, P. Corbeau, et al.. Galphai protein-dependant extracellular signal-regulated kinase-1/2 activation is required for HIV-1 reverse transcription. AIDS. Official journal of the international AIDS Society, 2008, 13, pp.1569-1576. ⟨10.1097/QAD.0b013e32830abdaf⟩. ⟨hal-00322412⟩
  • I. Du Chene, E. Basyuk, Yea-Lih Lin, R. Triboulet, A. Knezevich, et al.. Suv39H1 and HP1**g** are responsible for chromatin-mediated HIV-1 transcriptional silencing and post integration latency.. EMBO Journal, 2007, 26 (2), pp.424-435. ⟨10.1038/sj.emboj.7601517⟩. ⟨hal-00130455⟩
  • N. Bakkour, Yl. Lin, S. Maire, L. Ayadi, Florence Mahuteau-Betzer, et al.. Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance. PLoS Pathogens, 2007, 3 (10), pp.1530-1539. ⟨10.1371/journal.ppat.0030159⟩. ⟨hal-00259118⟩
  • N. Bakkour, Yea-Lih Lin, S. Maire, L. Ayadi, Florence Mahuteau-Betzer, et al.. Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance. PLoS Pathogens, 2007, 3 (10), pp.e159. ⟨10.1371/journal.ppat.0030159⟩. ⟨hal-00185296⟩
  • G. Petitjean, Y. Al Tabaa, E. Tuaillon, C. Mettling, V. Baillat, et al.. Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients. Retrovirology, 2007, 4, pp.60. ⟨10.1186/1742-4690-4-60⟩. ⟨hal-00194043⟩
  • C. Desmetz, Yea-Lih Lin, C. Mettling, P. Portales, D. Noel, et al.. Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytes.. Clinical Immunology, 2007, 123 (2), pp.148-154. ⟨10.1016/j.clim.2007.01.004⟩. ⟨hal-00148014⟩
  • C. Desmetz, Yea-Lih Lin, C. Mettling, P. Portales, H. Rabesandratana, et al.. The strength of the chemotactic response to a CCR5 binding chemokine is determined by the level of cell surface CCR5 density.. Immunology, 2006, 119 (4), pp.551-561. ⟨10.1111/j.1365-2567.2006.02470.x⟩. ⟨hal-00122082⟩

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Clément Mettling

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