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DTSTART;TZID=Europe/Paris:20250428T113000
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DTSTAMP:20260504T021615
CREATED:20250330T093059Z
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SUMMARY:The Natural and Sexual Selection of Endometriosis Risk by Prof. Bernard Crespi (Simon Fraser University\, Canada)
DESCRIPTION:I propose and evaluate a new theory for helping to explain the evolution of endometriosis risk in humans. By this theory\, endometriosis risk evolved in the context of sexual selection by males for high\, relatively female-biased expression of sexually dimorphic and female-limited phenotypes associated with low testosterone and high female reproductive fitness. The theory is supported by extensive data\, showing that: (a) endometriosis involves higher expression of major female-biasing genes\, and lower expression of major male-biasing genes\, that orchestrate prenatal sexual differentiation; (b) endometriosis and its correlates are associated with low prenatal and postnatal testosterone\, both of which have female-biasing effects on traits; (c) low prenatal and postnatal testosterone\, and endometriosis\, are associated with relatively female-biased phenotypic expression for a large suite of sexually dimorphic and sex-limited traits; (d) relatively female-biased expression of these traits is commonly associated with higher fertility and fecundity; (e) some traits\, including female facial features\, vocal pitch\, and breast size\, fit with all of the predictions of the model\, though they have yet to be studied specifically in relation to endometriosis; and (f) traits linked with low prenatal and postnatal testosterone or high estradiol\, and traits associated with endometriosis in humans\, are preferred by males across multiple species of non-human mammals. Risk and symptoms of endometriosis thus appear to involve and represent\, in part\, maladaptive extremes of sexually selected female-limited and sexually dimorphic traits. \n\n\n\n\n\nhttps://www.sfu.ca/biology/people/faculty/crespi.html \n\n\n\nContact: alexandra.alvergne[at]umontpellier.fr
URL:https://evoanth.cnrs.fr/lagenda1/the-natural-and-sexual-selection-of-endometriosis-risk-by-prof-crespi-simon-fraser-university/
LOCATION:Université Montpellier Campus Triolet ISEM Salle Louis Thaler Bât 22 1er étage\, Place Eugène Bataillon\, Montpellier\, Languedoc Roussillon\, 34095\, France
CATEGORIES:Conférences,Séminaires
ATTACH;FMTTYPE=image/jpeg:https://evoanth.cnrs.fr/wp-content/uploads/2025/03/pexels-photo-6542688.jpeg
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